*Designing Clinical Research (inkling)

2812-1804/9781608318049

ISBN
9781608318049
作者/出版社
Hulley /LWW
出版年代/版次
2013/4

定價NT$ 3,421
NT$ 3,250
數量
庫存不足

Description

Designing Clinical Research has been extensively revised and continues to set the standard as a practical guide for doctors, nurses, pharmacists, and other health professionals involved in all forms of clinical, translational, and public health research. It presents advanced epidemiologic concepts in a reader-friendly way, and suggests common sense approaches to the challenging judgments involved in designing, funding, and implementing.

New to this edition:

  • Expanded and updated content in every chapter, with new material on: • non-inferiority trials for comparative effectiveness research • incidence-density case-control studies • confounding and effect modification • diagnostic test studies to inform prediction rules • ethical aspects of whole genome sequencing • automated data management approaches • new NIH grant-writing requirements
  • Color format, and Electronic access, powered by Inkling™ as a free companion to the text • viewable through your browser or as a download to tablet or smartphone • the complete text with optimized navigation • note-sharing, highlighting and bookmarking capability • cross-linking of references and content • rapid search options linked to the new glossary

Features
4 -color design
New approaches to sample size estimation, keeping it simple while covering more design options
Examples and ideas on what's new in clinical research
Exercises that highlight major clinical research issues
Treatment of clinical trial design and implementation

Table of Contents

Section I
Basic Ingredients

1  Getting Started: The Anatomy and Physiology of Clinical Research
Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings

2  Conceiving the Research Question and Developing the Study Plan
Steven R. Cummings, Warren S. Browner, and Stephen B. Hulley

3  Choosing the Study Subjects: Specification, Sampling, and Recruitment
Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings

4  Planning the Measurements: Precision, Accuracy and Validity
Stephen B. Hulley, Thomas B. Newman and Steven R. Cummings 
5  Getting Ready to Estimate Sample Size: Hypotheses and Underlying Principles
Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley

6  Estimating Sample Size and Power: Applications and Examples
Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley

Section II
Study Designs

7  Designing Cross-Sectional and Cohort Studies
Stephen B. Hulley, Steven R. Cummings, and Thomas B. Newman

8  Designing Case–Control Studies
Thomas B.Newman, Warren S.Browner, Steven R.Cummings, and Stephen B.Hulley
    9  Enhancing Causal Inference in Observational Studies
Thomas B. Newman, Warren S. Browner, and Stephen B. Hulley 
10  Designing a Randomized Blinded Trial
Steven R. Cummings, Deborah Grady, and Stephen B. Hulley

11  Alternative Trial Designs and Implementation Issues
Deborah Grady, Steven R. Cummings, and Stephen B. Hulley

12  Designing Studies of Medical Tests
Thomas B.Newman, Warren S.Browner, Steven R.Cummings, and Stephen B. Hulley 
13  Research Using Existing Data
Deborah Grady, Steven R. Cummings and Stephen B. Hulley

Section III
Implementation

14  Addressing Ethical Issues
Bernard Lo and Deborah Grady

15  Designing Questionnaires, Interviews and Online Surveys
Steven R. Cummings, Michael A. Kohn, and Stephen B. Hulley

16   Data Management
Michael A. Kohn, Thomas B. Newman, and Stephen B. Hulley

17  Implementing the Study and Quality Control
Deborah Grady and Stephen B. Hulley

18  Community and International Studies
Norman Hearst and Thomas Novotny 
19  Writing and Funding a Research Proposal
Steven R. Cummings and Stephen B. Hulley

Exercises
Answers to Exercises
Glossary